Surena Vahabi; Mahshid Namdari; Mohammadreza Vatankhah; Kamyar Khosravi
Volume 22, Issue 9 , 2020
Abstract
Background: The use of evidence-based dentistry (EBD) as the integration of investigations and clinical decisions has been a focus of attention in recent years.
Objectives: The present study aimed to evaluate the knowledge, attitude, and practice of EBD among Iranian dentists in 2019.
Methods: A total ...
Read More
Background: The use of evidence-based dentistry (EBD) as the integration of investigations and clinical decisions has been a focus of attention in recent years.
Objectives: The present study aimed to evaluate the knowledge, attitude, and practice of EBD among Iranian dentists in 2019.
Methods: A total of 140 self-administered questionnaires with 57 items were distributed among dentists in the 2019 exhibition of Iranian dentists. Moreover, 60 self- administered questionnaires were sent to five different dentistry schools in Iran. The analyses were carried out using the Chi-square test, independent samples t-test, and Pearson correlation.
Results: A total of 119 fully-responded self-administered questionnaires were analyzed in this study. The dentists attending EBD workshops obtained significantly higher scores of knowledge. The Cochrane Library, manufacturers brochures, and evidence-based guidelines were used the least for clinical decisions. Consultation with colleagues, use of textbooks, and personal judgment were mostly utilized for clinical decisions. In addition, 93.3% of the participants stated sensible uncertainties in their clinical decisions. The most important barriers to EBD were the need for long discussions with patients, lack of skills in the critical appraisal of articles, and lack of motivation in dentists with the incidence rates of 62.2%, 62.2%, and 39.5%, respectively.
Conclusions: Due to the low levels of EBD knowledge among Iranian dentists, it is recommended to give further close attention to increasing the knowledge in this regard. However, their high enthusiasm for participation in EBD workshops and enhancement of EBD skills is promising.
Surena Vahabi; Bahareh Nazemisalman; Mahsa Kalantari; Sepanta Hosseinpour
Volume 21, Issue 1 , 2019, Pages 1-6
Abstract
Background: An imbalance in the expression of matrixmetalloproteinases (MMPs) and tissue inhibitormetalloproteinases initiatethe destructive process in chronic periodontitis (CP). C-reactive protein (CRP) is a systemic inflammatory mediator that reflects anacute immune response.Objectives: The purpose ...
Read More
Background: An imbalance in the expression of matrixmetalloproteinases (MMPs) and tissue inhibitormetalloproteinases initiatethe destructive process in chronic periodontitis (CP). C-reactive protein (CRP) is a systemic inflammatory mediator that reflects anacute immune response.Objectives: The purpose of this investigation was to analyze the association between the MMP-1 -1607 1G/2G (rs1799750) and CRP 717A/G (rs2794521) gene polymorphisms and chronic periodontitis in Iran.Methods: This analytical case-control study was performed among 141 participants including 63 CP cases and 78 matched healthyindividuals. Five milliliters of peripheral blood was collected for DNA isolation. Restriction fragment length polymorphism- polymerase chain reaction (RFLP-PCR) was performed for single-nucleotide polymorphism (SNP) analysis. The frequencies were analyzedby chi-squared test (95% CI, P < 0.05). In addition, genetic data were assessed by the Hardy-Weinberg principle, linkage disequilibrium, and haplotype analysis.Results: Our findings presented no significant relationship between genotype/alleles of MMP-1 -1607 1G/2G (rs1799750) (0.73: 0.27 -1.95, P = 0.48) or CRP 717 A/G (rs2794521) (0.384: 0.104 - 1.414, P = 0.303) and the presence of CP (P = 0.47 and P = 0.30, respectively).The analysis of genetic distribution among various severities of CP and controls revealed no significant association between variousseverities of CP and MMP-1 -1607 1G/2G (rs1799750) (P = 0.52) and CRP 717 A/G (rs2794521) (P = 0.67).Conclusions: Our results suggest no association between the occurrence or severity of chronic periodontitis and MMP-1 -1607 1G/2G(rs1799750) and CRP 717 A/G (rs2794521) polymorphisms. Further studies with larger sample sizes may provide a more generalizableevidence-based overview of the relationship between these gene polymorphisms and periodontitis.
